Norditropin Nordiflex


Norditropin Nordiflex


Norditropin Injection: (Somatropin) 10 mg Flexpro Pen 30 IU’s


The anabolic and growth-promoting actions of somatropin are indirectly mediated by somatomedins or insulin-like growth factors (IGFs). IGFs float around the body and attach to particular IGF receptors. IGF-1 and IGF-2 are the two known IGFs. Growth hormone appears to be primarily mediated by IGF-1, whereas IGF-2 has more insulin-like activity. The main anabolic effects of IGFs include inducing cell proliferation and growth, stimulating amino acid transport, and stimulating DNA, RNA, and protein synthesis. IGF-1 is directly in charge of chondrogenesis, skeletal development, and soft tissue expansion. By altering the cartilaginous growth regions of long bones, linear growth is encouraged. The quantity and size of skeletal muscle cells, the size of organs, and the activation of erythropoietin all contribute to the stimulation of growth. Growth hormones can affect the gut directly or indirectly through the local or systemic synthesis of IGF. Growth hormone has been found to improve the transmucosal transfer of nutrients, electrolytes, and water in in-vivo experiments. Glucocorticoids prevent these collateral effects.

Injected intramuscularly or subcutaneously, somatropin is given. Somatropin reaches its peak plasma concentrations 2 to 6 hours after dosing. Growth hormone-binding protein binds around 20% of the somatropin in circulation. IGF-1 plasma concentration peaks occur roughly 20 hours following somatropin treatment. The liver, kidney, and other tissues all metabolize somatropin. Glomerular filtration of somatropin occurs, and the kidney is where the molecule is broken down. The peptides and amino acids are released back into the bloodstream after being cleaved in the renal cells. Urine excretion is not very common. The half-life of plasma elimination is 20 to 30 minutes. The serum concentrations decrease with a half-life of roughly 3–5 hours as a result of the continuous release of somatropin from the intramuscular or subcutaneous location. The effects of somatropin extend considerably longer than its half-life of elimination due to the sluggish induction and clearance of IGF-1.


Novo Nordisk


There are no reviews yet.

Be the first to review “Norditropin Nordiflex”